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. 2021 Sep 12;116(1):51. doi: 10.1007/s00395-021-00891-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Right ventricular function at rest, during exercise and during cardiovascular magnetic resonance imaging in DM + HC + CKD and Healthy swine. Right ventricular afterload at rest and during exercise was similar as the maximal right ventricular pressure (RVP_max, A) and pulmonary arterial elastance (Ea, B) were similar between groups for any given level of body oxygen consumption (BVO₂). Systolic (dP/dt_max; maximum of the first derivate of the systolic RV pressure increase, E) and diastolic function (dP/dt_min; minimum of first derivate of the RV diastolic pressure decrease, F) were preserved in DM + HC + CKD swine for any level of heart rate. n = 11 for Healthy and n = 10 for DM + HC + CKD. Right ventricle cardiovascular magnetic resonance imaging parameters were measured under general anesthesia. End-diastolic (EDV, C) and end-systolic volume (ESV, D) ejection fraction (EF, G) and global longitudinal strain (GLS, H) were unaltered in DM + HC + CKD (n = 7) compared to Healthy swine (n = 6). Values are mean ± SEM