Table 1.

Schematic overview of swine used in various exercise protocols, as well as overlap between groups

Experiment	Con	ETA + Bi	NOSi	NOSi/ETA + Bi	PDE5i	ROSi
Con	Diseased 12 Healthy 11	Healthy 6	Healthy 7	Healthy 5	Healthy 6	Healthy 8
ETA + Bi	Diseased 6	Diseased 6 Healthy 6	Healthy 4	Healthy 5	Healthy 6	Healthy 5
NOSi	Diseased 6	Diseased 4	Diseased 6 Healthy 7	Healthy 5	Healthy 5	Healthy 4
NOSi/ETA+Bi	Diseased 4	Diseased 4	Diseased 3	Diseased 4 Healthy 6	Healthy 6	Healthy 6
PDE5i	Diseased 7	Diseased 4	Diseased 3	Diseased 3	Diseased 7 Healthy 7	Healthy 6
ROSi	Diseased 8	Diseased 5	Diseased 6	Diseased 3	Diseased 4	Diseased 8 Healthy 8

Numbers in bold denote the total numbers in a protocol, diseased reflect animal with DM + HC + CKD

Con control exercise experiment without pharmacological intervention, NOSi nitric oxide inhibition, ET_A + Bi endothelin receptor A and B antagonism, PDE5i phosphodiesterase 5 inhibition, ROSi scavenging of reactive oxygen species