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. 2021 Sep 11;12(9):843. doi: 10.1038/s41419-021-04137-1

Fig. 5. Effects of Liproxstatin-1 on RSL3-induced HK2 cells ferroptosis and profibrotic factor secretion.

Fig. 5

A The morphological of HK2 cells by a light microscope after the treatment for 24 h. B Viability of HK2 cells, evaluated by the CCK-8 assay (n = 3, **P < 0.01 vs control group; ##P < 0.01 vs RSL3 group). C Iron concentrations in HK2 cells (n = 6, *P < 0.05 vs control group; #P < 0.05 vs RSL3 group). D MDA levels in the HK2 cells (n = 6, **P < 0.01 vs control group; ##P < 0.01 vs RSL3 group). E Experimental design. F–H TGF-β1, CTGF, and PDGF levels in the HK2 cells conditioned medium (n = 3, **P < 0.01 vs control group; #P < 0.05, ##P < 0.01 vs RSL3 group). The data are presented as the mean ± SD.