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. 2021 Sep 11;12(9):843. doi: 10.1038/s41419-021-04137-1

Fig. 6. Effects of Liproxstatin-1 on GPX4 knockdown-induced HK2 cells ferroptosis and profibrotic factor secretion.

Fig. 6

A Protein expression of GPX4 in renal tissues of mice was detected by western blotting (n = 3, **P < 0.01 vs control group). B Viability of HK2 cells, evaluated by the CCK-8 assay (n = 5, **P < 0.01 vs control group; ##P < 0.01 vs GPX4 RNAi group). c Iron concentrations in HK2 cells (n = 3, **P < 0.01 vs control group; ##P < 0.01 vs GPX4 RNAi group). D–F TGF-β1, CTGF, and PDGF levels in the HK2 cells supernatant (n = 3, **P < 0.01 vs control group; #P < 0.05 vs GPX4 RNAi group). The data are presented as the mean ± SD.