FIG. 1.

EqHV infection typically resolves in horses. (A) Time points of clinical events and sampling (S). Intervals represent time spread for all sample types acquired. Horse D was chronically infected, and its POST sample represents another time point of FV. Horse J SC was the same time as FV and was excluded. (B,C) Serum viremia (B) and liver viral load (C) are shown for the course of primary EqHV NZP1 infection in horses. (D) Viremia during reinfection with homologous NZP1 inoculum, or the heterologous CU strain 1 month (n = 6, excludes horse D), or 1 year after homologous rechallenge (n = 2, horses N and P). Abbreviations: FV, falling viremia; HEP, hepatitis; LLOQ, lower level of quantification; PRE, preinoculation; SC, seroconversion.