TABLE 1.

Main dysregulated long non-coding RNAs in Alzheimer’s disease.

LncRNA	Target mRNA	AD-related process	Biological function	References
BACE1-AS	BACE1	Aβ deposition	Upregulating BACE1 mRNA stability	Faghihi et al., 2008; Shah et al., 2012; Cortini et al., 2019
XIST	BACE1	Aβ deposition	Upregulating BACE1 mRNA stability	Zhu et al., 2018; Yue et al., 2019
51A	SORL1	Aβ deposition	Downregulating SORL1 variant A	Ciarlo et al., 2013
Linc00507	MAPT/TTBK1	Tau hyperphosp horylation	Regulating the expression of MAPT and TTBK1	Yan et al., 2020
NEAT1	FZD3	Tau hyperphosp horylation	Impairing the FZD3/GSK3β/p-tau signaling pathway	Zhao et al., 2020
MALAT1	IL-10/SOC1	Neuroin flammation	Regulating the expression of IL-10 and SOC1	Masoumi et al., 2019; Ma et al., 2019
EBF3-AS	EBF3	Neuronal apoptosis	Promoting neuronal apoptosis in AD	Magistri et al., 2015; Gu et al., 2018
SNHG1	KRENEN1	Neuronal apoptosis	Target miR-137 to inhibit KREMEN1	Causeret et al., 2016; Wang et al., 2019