TABLE 2.

Main dysregulated long non-coding RNAs in Parkinson’s disease.

LncRNA	Target mRNA	AD-related process	Biological function	References
H19	HPRT1	Dopaminergic neuron loss	Upregulating HPRT1 mRNA stability	Li et al., 2016; Jiang et al., 2020
NEAT1	LRRK2	Dopaminergic neuron loss	Regulation of oxidative stress in dopaminergic neurons	Bastias-Candia et al., 2019; Simchovitz et al., 2019
SNHG1	SIAH1	α-synuclein aggregation	Promoting the ubiquitination of α-synuclein	Lee et al., 2008; Chen et al., 2018
LincRNA-p21	α-Synuclein	α-synuclein aggregation	Transcription repressor	Xu et al., 2018
GAS5	NLPR3	Neuroin flammation	Promoting inflammation of microglia	Xu et al., 2020b
HAGLROS	PI3K	Autophagy	Regulating the PI3K/AKT/mTOR signaling pathway	Peng et al., 2019