TABLE 3.

Main dysregulated long non-coding RNAs in Huntington’s disease and amyotrophic lateral sclerosis.

Disease	LncRNA	Target mRNA	Biological function	References
Amyotrophic lateral sclerosis	NEAT1/MALAT1	TDP-43	Improving toxicity of TDP-43	Hutchinson et al., 2007; Tollervey et al., 2011; Militello et al., 2018
	MEG3	Hox	promotes the formation of PRC2-Jarid2 complexes	Yen et al., 2018; Vangoor et al., 2020
	C9ORF72-AS	C9ORF72	Regulates repetition of (G4C2)n in C9ORF72	Kovanda et al., 2015; DeJesus-Hernandez et al., 2017; Shelkovnikova et al., 2018
Huntington’s disease	NEAT1	HTT/TP53	Reducing the expression of endogenous HTT and TP53.	Chanda et al., 2018
	TUG1	P53	Regulates P53 transcriptional regulatory pathway in HD	Khalil et al., 2009