TABLE 2.

Results of integrating enrichment analysis of biomarkers with MetaboAnalyst 5.0.

Pathway name	Match status	p	−log(p)	Holm p	FDR	Impact
Tyrosine metabolism	3/42	0.0047249	2.3256	0.39689	0.39689	0.12913
Phenylalanine, tyrosine and tryptophan biosynthesis	1/4	0.034051	1.4679	1.0	1.0	1.0
Linoleic acid metabolism	1/5	0.042394	1.3727	1.0	1.0	1.0
Taurine and hypotaurine metabolism	1/8	0.067028	1.1737	1.0	1.0	0.0
Phenylalanine metabolism	1/12	0.098964	1.0045	1.0	1.0	0.35714
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/14	0.11455	0.941	1.0	1.0	0.00399
Folate biosynthesis	1/27	0.20995	0.67789	1.0	1.0	0.0
Drug metabolism-cytochrome P450	1/27	0.20995	0.67789	1.0	1.0	0.0
Phosphatidylinositol signaling system	1/28	0.21688	0.66378	1.0	1.0	0.07388
Inositol phosphate metabolism	1/30	0.23057	0.63719	1.0	1.0	0.03345
Biosynthesis of unsaturated fatty acids	1/36	0.27033	0.5681	1.0	1.0	0.0
Glycerophospholipid metabolism	1/36	0.27033	0.5681	1.0	1.0	0.0
Amino sugar and nucleotide sugar metabolism	1/37	0.27677	0.55787	1.0	1.0	0.0
Arginine and proline metabolism	1/38	0.28316	0.54797	1.0	1.0	0.0
Primary bile acid biosynthesis	1/46	0.33242	0.47832	1.0	1.0	0.02285
Aminoacyl-tRNA biosynthesis	1/48	0.34423	0.46315	1.0	1.0	0.0