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. 2021 Aug 30;9:668164. doi: 10.3389/fcell.2021.668164

FIGURE 3.

FIGURE 3

Increased proliferation and angiogenesis and decreased apoptosis in CAF-co-transplanted, lung-seeded tumors is attenuated by TGFβ inhibition. (A,B) Representative p-SMAD3 IHC stained images and quantification in lung-seeded A223 tumors. Scale bar: 200 μm. (C,D) Representative cleaved-caspase 3 IHC stained images and quantification in lung-seeded A223 tumors. Scale bar: 200 μm. (E,F) Representative CD31 IHC stained images and quantification in lung-seeded A223 tumors. Scale bar: 200 μm. (G,H) Representative Ki67 IHC stained images and quantification in lung-seeded A223 tumors. Scale bar: 100 μm. nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001.