Table 1.
Clinical parameters and morphological & functional parameters of MGs for the 3 groups of study subjects
| Parameter |
Symptomatic groups |
Normal Control | P of trend value | ||
|---|---|---|---|---|---|
| MGD | Symptomatic non-MGD | ||||
| No. of subjects | 195 | 61 | 56 | ||
| Age, mean (SD), yrs | 34.47 (11.53) | 33.50 (12.36) | 31.65 (9.38) | 0.26 | |
| Sex, no. (%) | 0.15 | ||||
| Female | 118 (60.51) | 33 (54.09) | 40 (71.43) | ||
| Male | 77 (39.49) | 28 (45.91) | 16 (28.57) | ||
| Severity, no. (%) | <0.001 | ||||
| Grade 0 | 0 | 61 (100) | 56 (100) | ||
| Grade 1 | 47 (24.10) | 0 | 0 | ||
| Grade 2 | 64 (32.82) | 0 | 0 | ||
| Grade 3 | 47 (24.10) | 0 | 0 | ||
| Grade 4 | 28 (14.36) | 0 | 0 | ||
| Grade 5 | 9 (4.62) | 0 | 0 | ||
| Expressibility, no. (%) | <0.001 | ||||
| 0 | 9 (4.62) | 51 (83.61) | 44 (78.57) | ||
| 1 | 89 (45.64) | 10 (16.39) | 12 (21.43) | ||
| 2 | 63 (32.31) | 0 | 0 | ||
| 3 | 34 (17.44) | 0 | 0 | ||
| OSDI, mean (SD) | 25.87 (10.56) | 17.05 (6.55) | 3.89 (2.77) | <0.001 | |
| NI-BUT, mean (SD), s | 8.80 (4.81) | 12.95 (5.14) | 16.25 (4.92) | <0.001 | |
| MGYSS, mean (SD) | 24.18 (7.12) | 40.54 (6.30) | 41.59 (3.93) | <0.001 | |
| CFS score, mean (SD) | 0.87 (0.88) | 0.05 (0.22) | 0.00 | <0.001 | |
| ST I, mean (SD), mm | 12.25 (6.24) | 16.48 (6.05) | 16.39 (6.65) | <0.001 | |
| Morphological parameters | |||||
| DI, mean (SD) | 12.84 (5.77) | 9.62 (2.76) | 10.83 (2.87) | <0.001 | |
| TI, mean (SD) | 13.44 (2.77) | 14.90 (3.22) | 14.66 (2.46) | <0.001 | |
| GA, mean (SD), % | 41.07 (10.22) | 47.74 (6.67) | 47.25 (8.16) | <0.001 | |
| Functional parameter:SI range, no (%) | <0.001 | ||||
| SI<4.5 | 49 (25.13) | 6 (9.84) | 3 (5.36) | ||
| 4.5≤SI≤6.5 | 95 (48.72) | 42 (68.85) | 43 (76.79) | ||
| SI>6.5 | 51 (26.15) | 13 (21.31) | 10 (17.86) | ||
Abbreviations: MGs: meibomian glands; MGD: meibomian gland dysfunction; SD: standard deviation; OSDI: ocular surface disease index; NI-BUT: non-invasive tear film break-up; MGYSS: meibomian gland yield secretion score; CFS: corneal fluorescein staining score; ST I: Schirmer test I; DI: diameter deformation index; TI: tortuosity index; GA: gland area ratio, which is the ratio of all meibomian gland area to the total analysis area; SI: signal index of the glands.