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. 2021 Sep 8;15:100391. doi: 10.1016/j.ynstr.2021.100391

Fig. 2.

Fig. 2

SPS&S mice show enhanced fear responses to sound cues and impaired fear extinction. A Diagram of the training, extinction, and retrieval procedures. B Freezing times of SPS&S mice and control mice during the fear conditioning training on day 14. SPS&S mice exhibited a longer freezing time baseline and final freezing time after the sound cue stimulation session (Repeated measurement ANOVA, Fbetween group = 5.204, df1 = 1, df2 = 18, Pbetween group = 0.035; Fwithin group = 23.371, df1 = 5, df2 = 90, Pwithin group < 0.0001; n = 10 per group). C Compared with control mice, SPS&S mice exhibited longer freezing times in Context B during the sound cue stimulation (Two-tailed unpaired t-test, t = 4.067, df = 18, P = 0.0007, n = 10 per group). D Compared with control mice, SPS&S mice exhibited a longer freezing time baseline before and after extinction of fear memory in Context B (Repeated measurement ANOVA, Fbetween group = 34.411, df1 = 1, df2 = 18, Pbetween group < 0.0001; Fwithin group = 27.781, df1 = 1.539, df2 = 27.708, Pwithin group < 0.0001, n = 10 per group). *P < 0.05, ****p < 0.0001.

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