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. 2021 Aug 30;9:720900. doi: 10.3389/fcell.2021.720900

FIGURE 1.

FIGURE 1

The miR-379/miR-544 cluster expression is upregulated in the steatotic liver of db/db mice and HFD-fed mice. (A) Heatmap showing relative miRNA expression between wild-type (wt) and db/db mice (n = 4). The higher and lower expression is showed with red and blue color, respectively. Nine significantly upregulated miRNAs (miR-379, miR-411, miR-299, miR-679, miR-543, miR-300, miR-134, miR-541, and miR-337-5p) located in the miR-379/miR-544 cluster are shown with bold font. Differentially regulated miRNAs are defined with fold changes ≥ 2-fold, P < 0.05. (B,C) Hepatic expression levels of miR-379, miR-411, and miR-543 were determined by real-time PCR in chow-fed 10-12-week-old db/db mice (B) and WT mice (n = 4) fed an HFD for 10 weeks starting at 4 weeks of age (C). *P < 0.05 and **P < 0.01.