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. 2021 Aug 30;9:720900. doi: 10.3389/fcell.2021.720900

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Copyright © 2021 Cao, Duan, Li, Guo, Zhang, Gui and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-379/miR-544 cluster KO-HFD mice display dysregulation of hepatic gene expression. (A) Volcano plot showing differential expression of 761 significantly altered genes that determined by RNA-seq (n = 3). (B) Venn diagram showing a comparison between significantly upregulated genes and genes predicted to be miR-379/miR-544 cluster targets by Targetscan and microCosm. (C) Schematic representation of the predicted metabolic genes targeted by miR-379/miR-544 cluster on glucose and triacylglycerol metabolism processes. (D) Schematic diagram of the working model of miR-379/miR-544 cluster in liver metabolic regulation. Igf1r, a transmembrane tyrosine kinase receptor, is a target of miR-379 that regulates the TCA cycle. Dlk1 is a target gene of miR-329 and involves in fatty acid oxidative metabolism. The miR-379/miR-544 cluster is proposed to be an integral component of a regulatory circuit that functions under conditions of metabolic stress to control the overall energy homeostasis.