Figure 4.

A matrisome signature containing versican (A) positively correlates with Th2 and T regulatory expression and (B) negatively correlates with cytotoxic T cell markers. Meta-analysis on RNA-seq data from Pearce et al. (19). Analysis was completed on 33 patient samples of high-grade serous ovarian cancer omental metastasis. The matrix index refers to a signature of 22 matrisome genes identified in the paper with values determined from a ratio of upregulated and downregulated genes. Versican is one of six genes that were upregulated in tumours. Spearman rank correlation was used to compare matrix index values from immune cell expression (19, 79). P-values were FDR corrected using the Benjamini & Hochberg method. The average expression of PRF1 and GZMB (genes associated with cytotoxic T cells) was correlated to matrix index values from 11 poor prognostic patients using Pearson’s correlation. Th2, T helper cells; Treg, T regulatory cells; PRF1, perforin 1; GZMB, granzyme B.