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. 2021 Aug 30;12:701065. doi: 10.3389/fgene.2021.701065

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Copyright © 2021 Ye, Wang, Yang, Hu, Zhang, Tong, Liu and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of immune subtypes of GBM based on the consensus clustering of the abundance of 22 kinds of tumor immune infiltrating cells (TIICs). (A) Consensus clustering matrix of 169 The Cancer Genome Atlas (TCGA)-GBM samples for k = 2 and (B) k = 3. (C) Consensus clustering CDF for k = 2 to k = 9. (D) Relative change in area under CDF curve for k = 2 to k = 9. (E) Survival analysis between the OS and two subtypes. Distribution ratio of (F) IDH mutation status, (G) 1p19q co-deletion status, (H) age group (cut off: 60 years old), and (I) survival status among immune subtype 1 (IS1)-immune subtype 2 (IS2) in TCGA-GBM. (J) The difference analysis of the abundance of immune cells and the stromal and immune scores in IS1 and IS2. Fustat: survival status. ***p < 0.001, **p < 0.01, *p < 0.05, ns: not significant.