Figure 7.

Schematic representation of Pam2CSK4 effects in platelets and platelet-HUVECs interactions. Activation of the TLR2/TLR6 complex by Pam2CSK4 initiates a series of signaling events involving BTK and NF-κB to promote platelet activation. Functional responses triggered by Pam2CSK4 include δ- and α-granule secretion as well as integrin activation and subsequent aggregation. Activation of platelet TLR2/TLR6 also promotes the adhesion of platelets to endothelial cells and increase endothelial cell inflammation. BTK, Bruton`s tyrosine kinase; HUVECs, Human umbilical vein endothelial cells; ICAM-1, intercellular adhesion molecule 1; TLT1, Trem-like transcript 1; NF-κB, nuclear factor-κB; GPVI, glycoprotein VI. Image created with BioRender.com.