Figure 2.

Binding sites of FDA-approved mAbs therapeutics on EBOV GP. (A) Crystal structure of GP Muc interacting with Fabs of mAb114. Fabs are shown in pink (heavy chain) and white (light chain). GP Muc promoters are in green and beige for molecular surfaces while the third is represented by ribbon strings. (B) Relative binding sites of REGN-EB3 on EBOV GP. adapted from ref (20). REGN3471, REGN3470, and REGN3479 combined reconstructions on a single EBOV GPΔTM, demonstrating the relative locations of the epitopes on GP from the three competition groups. Only one Fab is shown per antibody.