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. 2021 Aug 30;11:725284. doi: 10.3389/fcimb.2021.725284

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Copyright © 2021 Zhao, An, Wang, Shan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Key discriminatory metabolites were identified by clustering and multivariate correlation analysis between HC group and LC group. (A) Hierarchical clustering analyses (HCA) was based on the relative abundance of normalized numbers of metabolomics data from HC and LC group. (B) OPLS-DA scores displaying the discrimination between HC group and LC group by the first two principal components (PCs). (C) Important discriminatory metabolites displayed on variable importance in projection (VIP) plot obtained from OPLS-DA.