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. 2021 Aug 30;12:704655. doi: 10.3389/fimmu.2021.704655

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Copyright © 2021 Fu, Liu, Han, Pan, Wang, Wang, Dai and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment analysis of the 25 genes in signature and the correlations of the prediction score with the expressions of immune checkpoints. (A) Significantly enriched GO terms and (B) significantly enriched immune-related KEGG pathways. LOC102723479 is replaced with official gene symbol of IGHG1 by querying in the NetAffx Analysis Center and verified by BLAST search in NCBI database using probe sequence. (C) The prediction scores of the classifier show significant positive correlations with the expression of the immune checkpoints, especially with CTLA4, LAG3, and IDO1.