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. 2021 Aug 30;12:715986. doi: 10.3389/fphar.2021.715986

FIGURE 4.

FIGURE 4

- Effect of myeloid cell and myofibroblast Gal-3 depletion on bleomycin induced fibrosis. Bleomycin was administered i. t. to LysM-cre - , LysM-cre + , Pdgfrb-cre -- Pdgfrb-cre + mice or global Gal-3 −/− mice. Lungs were retrieved on day 21. (A) Lung sections from LysM-cre +/- and Gal-3 −/− mice 21 days after bleomycin administration, stained with Masson’s trichrome (purple) to identify fibrosis. (B) Fibrosis score, lung collagen, BAL total protein and BAL Gal-3 from LysM-cre +/- and Gal-3 −/− mice 21 days after bleomycin administration. (C) Effect of mesenchymal cell Gal-3 depletion 21 days after bleomycin administration. Data represented as mean ± SEM. Analysed via 1-way ANOVA (B) or student’s t-test (C) (n = 4-5, **p < 0.01, ***p < 0.001).