Table 4. Molecular-pathological parameters of tumors related to establishment of HCC PDXs.
| Parameters | n (%) | P | |
| Successful
(N=30) |
Failed
(N=46) |
||
| The positive and negative expression of Ki67 was defined by the cut-off value of nucleus-positive rate. HCC, hepatocellular carcinoma; PDX, patient derived xenograft; AFP, alpha-fetoprotein; GPC3, glypican-3; CK19, cytokeratin 19; EpCAM, epithelial cell adhesion molecule. | |||
| Tumor size (cm) | 0.572 | ||
| ≤5 | 19 (63.3) | 32 (69.6) | |
| >5 | 11 (36.7) | 14 (30.4) | |
| Tumor differentiation | 0.001 | ||
| Well and Moderate | 11 (36.7) | 35 (76.1) | |
| Poor | 19 (63.3) | 11 (23.9) | |
| Satellite lesions | 0.074 | ||
| Yes | 8 (26.7) | 5 (10.9) | |
| No | 22 (73.3) | 41 (89.1) | |
| Vascular invasion | 0.011 | ||
| No | 12 (40.0) | 33 (71.7) | |
| Microvascular | 10 (33.3) | 10 (21.7) | |
| Macrovascular | 8 (26.7) | 3 (6.6) | |
| Histological subtyping | 0.044 | ||
| Microtrabecular | 4 (13.3) | 16 (34.8) | |
| Macrotrabecular | 19 (63.3) | 16 (34.8) | |
| Compact | 2 (6.7) | 8 (17.4) | |
| Pseudoglandular | 5 (16.7) | 6 (13.0) | |
| AFP expression | 0.075 | ||
| Positive | 13 (43.3) | 11 (23.9) | |
| Negative | 17 (56.7) | 35 (76.1) | |
| GPC3 expression | 0.006 | ||
| Positive | 26 (86.7) | 26 (56.5) | |
| Negative | 4 (13.3) | 20 (43.5) | |
| Ki67 expression | <0.001 | ||
| Positive | 27 (90.0) | 18 (39.1) | |
| Negative | 3 (10.0) | 28 (60.9) | |
| CK19 expression | 0.034 | ||
| Positive | 10 (33.3) | 6 (13.0) | |
| Negative | 20 (66.7) | 40 (87.0) | |
| CD133 expression | 0.039 | ||
| Positive | 14 (46.7) | 11 (23.9) | |
| Negative | 16 (53.3) | 35 (76.1) | |
| EpCAM expression | 0.555 | ||
| Positive | 11 (36.7) | 20 (43.5) | |
| Negative | 19 (63.3) | 26 (56.5) | |