FIGURE 5.
LA defibrillation attempts with Ee = 0.05 mW/mm2 in model A01 for all three opsins. The control case (A) is compared to endocardial illumination of ChR2- (B), ChR2-RED- (C), or GtACR1- (D) expressing models. Arrows indicate wavefront propagation directions. Double lines show sites of conduction block. Representative Vm(t) traces are shown from endocardial (red line) and epicardial (blue line) nodes at the same point on the LA posterior wall (green dot); shaded regions in rows (B–D) indicate illumination intervals. All illumination begins at t = 0 ms and lasts 1000 ms.