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. 2021 Aug 30;12:718622. doi: 10.3389/fphys.2021.718622

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Copyright © 2021 Ochs, Karathanos, Trayanova and Boyle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative example of LV defibrillation attempt in GtACR1-expressing model V01 with E_e = 0.5 mW/mm². V_m(t) traces from the LV endocardial surface are provided for the control case (A) and GtACR1-expressing model (B). Green shaded region in (B) shows illumination interval. Cut plane V_m(t) snapshots of the GtACR1 case (C) show conduction block affecting wavefront propagating circumferentially in LV free wall, followed by eventual arrhythmia termination. Arrows indicate wavefront propagation directions. Double lines show sites of conduction block.