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. 2021 Aug 30;13:718850. doi: 10.3389/fnagi.2021.718850

FIGURE 3.

FIGURE 3

CBD inhibits THC metabolism. Fat THC and its metabolites as well as CBD concentrations were determined at various time-points, on the last treatment day (day 28), 2 weeks post-treatment (day 42), and 3 weeks post-treatment (day 50). (A) Fat THC levels were significantly altered based on time and the type of treatment. Data represented as mean ± SEM, **p < 0.01; ****p < 0.0001; +p < 0.05 (difference in fat THC levels at day 42 between THC and THC/CBD groups); 2-way ANOVA with Tukey’s multiple comparison test. (B) Fat CBD concentrations in the THC/CBD group significantly decreased over-time. Data represented as mean ± SEM, ****p < 0.0001 (difference in fat CBD levels between day 28 and day 42 or day 50); 1-way ANOVA with Tukey’s multiple comparison test. (C) Increased fat 11-OH-THC, metabolite of THC in the presence of CBD at day 28. No fat THC metabolites are detected at day 42 and day 50 (n = 7–8 mice per group). Data represented as mean ± SEM, ****p < 0.0001 (difference in fat 11-OH-THC levels at day 28 between THC and THC/CBD groups); 2-way ANOVA with Tukey’s multiple comparison test.