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. 2021 Aug 30;12:654951. doi: 10.3389/fphys.2021.654951

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Copyright © 2021 Fan, Zhao, Ma and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNA GAS5 regulated PTEN by competitively binding to miR-21. (A,B) Bioinformatics analyses showed that there were specific binding sites between lncRNA GAS5 and sequences of miR-21 (A) and between the 3′ UTR of the PTEN gene and sequences of miR-21 (B). (C) miR-21 inhibitor increased PTEN and attenuated lncRNA GAS5 siRNA-induced EMT of HPMCs. (D) PTEN reversed the lncRNA GAS5 siRNA-induced EMT of HPMCs. Each value represents the mean ± SEM (n = 3) (**P < 0.01 vs. control, ^&⁣&P < 0.01 vs. siGAS5).