Table 2.
Screening of amino acids and derivatives between the ROP group and the control group by targeted metabolomics.
| Metabolite name | Transitions | Average concentration of ROP (µM) | Average concentration of control (µM) | Fold change | p-value | FDR |
|---|---|---|---|---|---|---|
| citrulline | 176.1/159.2 | 39.6513 | 30.7085 | 1.2912 | 0.0012 | 0.0372 |
| creatinine | 114.1/44.0 | 11.4593 | 14.3750 | 0.7972 | 0.0036 | 0.0558 |
| arginine | 175.1/70.0 | 77.8832 | 61.4484 | 1.2675 | 0.0109 | 0.1126 |
| aminoadipic acid | 162.0/98.0 | 4.3091 | 2.5833 | 1.6681 | 0.0258 | 0.2000 |
| tyrosine | 182.1/136.1 | 101.1252 | 118.0665 | 0.8565 | 0.0507 | 0.3143 |
| lysine | 147.1/84.0 | 229.0000 | 195.8406 | 1.1693 | 0.0815 | 0.3933 |
| cystine | 241.1/151.9 | 99.4454 | 116.9984 | 0.8500 | 0.0888 | 0.3933 |
| tryptophan | 205.1/146.3 | 62.3735 | 55.9101 | 1.1156 | 0.1185 | 0.4242 |
| isoleucine | 132.1/86.2 | 61.1096 | 70.0279 | 0.8726 | 0.1307 | 0.4242 |
| asparagine | 133.1/74.2 | 65.1200 | 71.5070 | 0.9107 | 0.1440 | 0.4242 |
| hydroxyproline | 132.1/86.1 | 92.0505 | 80.2571 | 1.1469 | 0.1524 | 0.4242 |
| aspartate | 134.0/74.1 | 34.8977 | 25.6973 | 1.3580 | 0.1642 | 0.4242 |
| choline | 104.1/60.0 | 160.7088 | 125.7474 | 1.2780 | 0.1931 | 0.4605 |
| histidine | 156.1/110.1 | 288.7739 | 202.3598 | 1.4270 | 0.2181 | 0.4829 |
| glutamine | 147.0/84.1 | 825.4253 | 868.8833 | 0.9500 | 0.2372 | 0.4902 |
| creatine | 132.1/90.0 | 67.7460 | 63.2528 | 1.0710 | 0.3064 | 0.5673 |
| glycine | 76.0/30.1 | 334.3902 | 366.2055 | 0.9131 | 0.3111 | 0.5673 |
| methionine | 150.1/133.0 | 49.6478 | 44.5628 | 1.1141 | 0.3506 | 0.5804 |
| proline | 116.1/70.1 | 201.5363 | 210.6346 | 0.9568 | 0.3557 | 0.5804 |
| spermidine | 146.2/72.2 | 13.2098 | 7.3157 | 1.8057 | 0.3768 | 0.5840 |
| serine | 106.0/60.0 | 167.9776 | 189.2015 | 0.8878 | 0.3985 | 0.5883 |
| taurine | 126.0/44.1 | 145.3126 | 239.9024 | 0.6057 | 0.4326 | 0.6096 |
| alanine/sarcosine | 90.1/44.0 | 385.9632 | 368.7197 | 1.0468 | 0.4743 | 0.6205 |
| glutamate | 148.1/84.1 | 162.3295 | 173.6118 | 0.9350 | 0.4804 | 0.6205 |
| ornithine | 133.1/70.1 | 117.3583 | 122.2741 | 0.9598 | 0.5054 | 0.6254 |
| cysteine | 122.1/59.0 | 3.2110 | 3.2456 | 0.9893 | 0.5245 | 0.6254 |
| putrescine | 89.0/72.0 | 0.3470 | 0.3151 | 1.1011 | 0.5940 | 0.6820 |
| phenylalanine | 166.1/103.1 | 72.5253 | 75.6784 | 0.9583 | 0.6607 | 0.7315 |
| leucine | 132.1/86.2 | 106.3011 | 108.9801 | 0.9754 | 0.6969 | 0.7450 |
| valine | 118.1/72.1 | 208.3944 | 198.6853 | 1.0489 | 0.7337 | 0.7582 |
| threonine | 120.0/74.0 | 258.8024 | 255.8157 | 1.0117 | 0.9961 | 0.9961 |
FDR, false discovery rate.