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. 2021 Aug 3;18(15):3425–3436. doi: 10.7150/ijms.63541

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Protein-protein interaction network cluster analysis. The PPI network of differentially expressed genes in EC versus Ctrl or EU versus Ctrl was constructed using the STRING website. The MCODE clustering algorithm was applied to the network to identify the potential hub genes. Top two clusters in each group are shown in the figure. In the EC-associated PPI network, cluster 1 consists of 11 nodes and 31 edges (A) and cluster 2 consists of 11 nodes and 31 edges (B). In the EU-associated PPI network, cluster 1 consists of 21 nodes and 209 edges (C) and cluster 2 consists of 11 nodes and 55 edges (D). PPI: protein-protein interaction; STRING, search tool for retrieval of interacting genes/proteins.