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The metalloproteinase superfamily. The basic structural organisation of ADAMTS, ADAM and MMPs family members (including MMPs with a transmembrane domain, MT-MMP). Metalloproteinases generally contain similar proteinase domains. Differences in structure can be seen at the C-terminus or at the ancillary domain where ADAMTS enzymes contain Thrombospondin repeats; ADAMs are membrane-anchored through a transmembrane domain; and MMPs contain haemopexin-like regions.
