Fig. 5.

Comparison of circulating PCSK9 concentrations in several biological compartments. A: PCSK9 concentrations in plasma collected from the tail or portal or mesenteric lymph, bile, urine, and intestinal lumen from C57BL6/J female mice were measured by ELISA. B: PCSK9 concentrations in plasma from cheek vein blood and portal vein blood from PCSK9 LivKO mice or control floxed male and female mice. Scatter dot plots + bars represent the median ± interquartile. ∗∗∗P < 0.001 versus cheek vein blood in males. §§P < 0.01 versus portal vein blood in males. PCSK9 LivKO, mouse model lacking PCSK9 specifically in hepatocytes; PCSK9, proprotein convertase subtilisin/kexin type 9.