Table 2.

Knockdown of Notch4 Suppresses Notch4 Oncogenic Signaling in Cancer

Cancer type	Observations	Reference
Salivary adenoid cystic carcinoma	Silencing of Notch4 by si-RNA inhibited tumor cell invasion in vitro.	[43]
Breast carcinoma	Silencing of Notch4 by si-RNA inhibited the stemness, mammosphere formation, migration, and EMT of CSCs in vitro.	[22]
	Silencing of Notch4 by si-RNA inhibited the proliferation, colony formation and invasiveness of tumor cells in vitro and inhibited the tumorigenicity and tumor volume in vivo.	[23]
	Silencing of Notch4 by sh-RNA reduced mammosphere colonies and tumor formation both in vivo and in intro	[36]
	Silencing of Notch4 by si-RNA inhibited CSC activity in vitro.	[38]
Colon carcinoma	Silencing of Notch4 by si-RNA inhibited the gene expression of stemness’s markers of tumor cells in vitro.	[39]
Melanoma	Silencing of Notch4 by sh-RNA inhibited the invasion, migration, and VM formation of tumor cells in vitro.	[45]
Oral squamous cell carcinoma	Silencing of Notch4 by si-RNA inhibited the proliferation and migration of tumor cells in vitro.	[51]
Pancreatic carcinoma	Silencing of Notch4 by si-RNA inhibited the viability, migration, invasion and drug resistance of tumor cells in vitro.	[60]
Hepatocellular carcinoma	Silencing of Notch4 by si-RNA inhibited the invasion and vasculogenic mimicry formation of tumor cells in vitro.	[70]
Prostate carcinoma	Silencing of Notch4 by si-RNA inhibited the growth, migration, invasion and EMT of tumor cells in vitro.	[72]
Head and neck squamous cell carcinoma	Silencing of Notch4 by si-RNA inhibited the proliferation, EMT and drug resistance of tumor cells in vitro.	[46]