Table 3.

Multiple miRNAs Inhibit Cancer Progression by Negatively Regulating Notch4

miRNA	Cancer Type	Observations	Reference
miR-7	Hepatocellular carcinoma	MiR-7 suppresses the vasculogenic mimicry formation of HCC by targeting Notch4.	[71]
miR-34a	Pancreatic Ductal Carcinoma	MiR-34a suppresses the survival, invasion and migration of tumor cells and tumor growth by targeting Notch1, 2 and 4.	[74]
miR-34c	Breast carcinoma	MiR-34c suppresses the self-renewal, migration and EMT process of tumor-initiating cells by targeting Notch4.	[51]
miR-96 and miR-183	EBV-associated nasopharyngeal carcinoma	MiR-96 and miR-183 suppress the growth, colony formation and the stem cell-like of tumor cells by inhibiting the expression of NICD3 and NICD4.	[75]
miR-181c	Gastric carcinogenesis	MiR-181c suppressed tumor cell proliferation by targeting Notch4 and KRAS.	[76]
miR-302	Melanoma	MiR-302 suppresses the tumorigenic phenotype of aggressive tumor cells by targeting Notch4.	[47]
miR-1179	Breast carcinoma	MiR-34a suppresses the proliferation, invasion and migration of tumor cells by targeting Notch1, 4 and Hes1.	[77]