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. 2021 Aug 30;12:728261. doi: 10.3389/fphar.2021.728261

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Copyright © 2021 Mu, Ma, Chen, Zhang and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Luteolin increases intracellular Collagen I expression and reduces ROS accumulation. (A) luteolin reduced intracellular ROS accumulation. (B) Representative image of immunofluorescence staining for MMP-1 and Collagen I. (C) luteolin reduced intracellular levels of MMP-1. (D) luteolin increased intracellular levels of Collagen I. # indicates significant difference between the model group and the blank group (#p < 0.05; ##p < 0.01); * indicates significant difference between the administered group and the model group (*p < 0.05; **p < 0.01).