Table 3.

Next-generation sequencing derived differential gene expression (FPKM, P  < 0.05, n = 4) of a selected set of key-metabolism genes involved in glucose and lipid metabolism in brown and white adipose tissue after systemic silencing of miR-224 and miR-452 in mice.

	Glucose metabolism	Lipid metabolism	Fatty acid metabolism	Mitochondrial energy metabolism
BAT
AntimiR-224 - BAT	Irs1↓, Irs2↓, Eif4ebp1↑, Frs2↓, Jun↓, Fbp1↑, Pik3ca↑	Cidea↑, Fabp4↑, Acaa2↑, Apoc1↑, Pdhb↑, Pdk4↓, Idh3b↑, Suclg1↑, Acaa1a↑, Acca2a↑, Acat1↑, Acadvl↑, Acsl3↓	Fabp5↑, Slc27a3↓	Ppargc1a↓, Cox5b↑, Cox6b1↑, Cox6c↑, Cox7a2↑, Cox7a2l↑, Cox7b↑, Cyc1↑, Ndufa1↑, Ndufa11↑, Ndufa2↑, Ndufa3↑, Ndufa4↑, Ndufa6↑, Ndufa7↑, Ndufa8↑, Ppa2↑, Sdhb↑, Slc25a21↓, Ucp3↓,
AntimiR-452 - BAT	Insr↓, Irs2↓, Pfkfb3↓, Sorbs1↓, Pdpk1↓, Pir3cb↓, Prkc1↓, Srebf1↓, Sorbs1↓, Frs2↓	Scd2↓, Srebp1c↓, Acsl1↓	Prkaa1↓, Prkacb↓	Ppargc1a↓, Atp6voa2↓, Cox6c↑, Lhpp↑, Slc25a15↓, Ucp2↑
WAT
AntimiR-224 - WAT	Igf1r↑, Grb2 ↑, Ptpn1↑, Ptprf↑, Adra1d↓, Srebf1↓, Glut4↓, PI3K↑, mTOR↓	Gpr120↓, Mlxipl↓, Acc1↓, Acc2↓, Srebp1c↓, Hsl↓, Acsl1↓, Apoc1↓	Acads↓, Acsl5↑, Cpt1a↑, Crat↓, Hadha↓, Lipe↓, Hmgcs2↑	Ucp2↑, Cox7a2l↑, Gadd45b↑
AntimiR-452 - WAT	Gys1↓, Fbp2↑, Igf1r↑, Igfbp1↑, Ptprf↑, Araf↑	Gpr120↓, Mlxipl↓, Acc1↓, Apoc1↓	Slc27a2↑, Prkacb↑	Slc25a15↑, Slc25a21↑