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. 2021 Aug 26;64(17):12603–12629. doi: 10.1021/acs.jmedchem.1c00497

Scheme 2. (a) K2CO3, CH3CN, 60 °C, 48 h; (b) HCl/EtOAc 12 h, rt; and (c) Cs2CO3, 4-Dimethylaminopyridine (DMAP), DCM, rt, 12 h.

Scheme 2