Table 3. Functional Data for the Selected Compoundsb.
| antagonist
effect pKB ± SEM |
||||
|---|---|---|---|---|
| compd | 5-HT6R | 5-HT7R | D2R | 5-HT2AR |
| 2 | 7.26 ± 0.01 | 7.06 ± 0.02 | 7.62 ± 0.01 | 8.22 ± 0.20 |
| 3 | 7.02 ± 0.01 | 6.85 ± 0.01 | 7.81 ± 0.01 | 8.40 ± 0.34 |
| 5 | 7.41 ± 0.02 | 7.26 ± 0.01 | 7.22 ± 0.02 | 7.96 ± 0.04 |
| 7 | 7.44 ± 0.03 | 7.42 ± 0.03 | 8.21 ± 0.01 | 7.99 ± 0.07 |
| 11 | 7.12 ± 0.01 | 7.36 ± 0.01 | 7.34 ± 0.03 | 7.81 ± 0.58 |
| 15 | 6.82 ± 0.02 | 7.12 ± 0.01 | 6.87 ± 0.01 | 6.82 ± 0.01 |
| 16 | 6.74 ± 0.05 | 6.40 ± 0.01 | 6.73 ± 0.02 | 7.79 ± 0.58 |
| 18 | 6.41 ± 0.02 | 5.62 ± 0.01 | 6.79 ± 0.01 | 8.30 ± 0.19 |
| 21 | 6.77 ± 0.07 | 6.34 ± 0.02 | 6.60 ± 0.02 | 7.63 ± 0.01 |
| SB-42457 | 9.47 ± 0.01 | |||
| SB-269970 | 9.7 ± 0.01 | |||
| Chlorpromazine | 8.80 ± 0.0 | |||
| Pimavanserin | 9.17 ± 0.01 | |||
a
All of the functional activity values were expressed as mean from at least three experiments performed in duplicate.
b
Blank spaces—compounds not tested in the assays.