Table 4. Off-Target Activity Data for the Selected Molecules.

	% activity at 1.0 × 10–6 Ma
compd	H1R (%)	α1R (%)	M1R (%)	hERGb (%)
2	39	48	–15	23
3	58	66	5	34
5	54	39	4	31
7	29	56	–7	28
11	24	43	–5	29
15	10	13	11	29
16	2	14	–1	40
18	19	19	7	38
21	4	15	–6	47
Phentolamine	91	76
Mepyramine	95		55
Amitriptyline	99	82	78
Doxepin	97		92
Quetiapine	76	75	88
Olanzapine	89	82	89
Verapamil				91

^a% inhibition of control specific binding at the concentration of 1.0 × 10^–6 M. Assays carried out in duplicate (n = 2). Blank spaces—compounds not tested in the assay.

^b% inhibition of hERG-mediated potassium currents at a concentration of 1.0 × 10^–6 M.