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. 2021 Aug 26;64(17):12603–12629. doi: 10.1021/acs.jmedchem.1c00497

Table 5. Thermodynamic Solubility Data of Selected Compounds.

compda aqueous solubility μg/mL
2 128.38 ± 1.61
3 132.7 ± 0.74
5 62.44 ± 1.05
7 204.75 ± 1.68
11 306.29 ± 0.80
15 <0.1
16 1.62 ± 0.1
18 9.16 ± 0.42
21 <0.1
Metoprolol 193 ± 1.02
a

Prior to the measurement, compounds were converted to the corresponding hydrochloride salts.