Table 5. Thermodynamic Solubility Data of Selected Compounds.
| compda | aqueous solubility μg/mL |
|---|---|
| 2 | 128.38 ± 1.61 |
| 3 | 132.7 ± 0.74 |
| 5 | 62.44 ± 1.05 |
| 7 | 204.75 ± 1.68 |
| 11 | 306.29 ± 0.80 |
| 15 | <0.1 |
| 16 | 1.62 ± 0.1 |
| 18 | 9.16 ± 0.42 |
| 21 | <0.1 |
| Metoprolol | 193 ± 1.02 |
Prior to the measurement, compounds were converted to the corresponding hydrochloride salts.