Table 6. Pharmacokinetic Parameters (Mean ± Standard Deviation (SD)) of the Studied Compounds Administered to Ratsa at a Dose of 2 mg/kg i.p. Using Noncompartment Analysis.
| parameter | 7 | 11 | 16 |
|---|---|---|---|
| tmax (min) | 22.5 ± 10.61 | 8.3 ± 5.77 | 5.0 ± 0.00 |
| Cmax (ng/mL) | 193.44 ± 49.76 | 69.68 ± 5.86 | 179.33 ± 34.11 |
| λz (min–1) | 0.007 ± 0.0003 | 0.002 ± 0.0002 | 0.013 ± 0.0009 |
| t0.5λz (min) | 96.09 ± 4.25 | 318.59 ± 26.46 | 55.67 ± 4.09 |
| AUCinf (ng·min/mL) | 36 269.95 ± 8836.54 | 17 368.37 ± 1680.24 | 7060.67 ± 1056.47 |
| Vz/F (L/kg) | 7.96 ± 2.34 | 52.99 ± 6.05 | 23.04 ± 3.21 |
| CL/F (L/(min kg)) | 0.06 ± 0.01 | 0.12 ± 0.01 | 0.29 ± 0.05 |
| MRT (min) | 146.10 ± 4.67 | 435.68 ± 39.99 | 64.98 ± 4.06 |
a
The PK studies and all of the in vivo studies were conducted using male Wistar rats (n = 3).