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SAR studies of bisubstrate NNMT inhibitors 21a–k bearing different amino acid substitutions and compounds 24a, 24b, and 32 lacking either the adenosine unit or the nicotinamide-mimicking aromatic side chain. IC50 values (μM) and s.e.m. values are shown in red. Changes introduced relative to the lead inhibitor 17u are indicated in blue.
