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. 2021 Aug 23;64(17):12938–12963. doi: 10.1021/acs.jmedchem.1c01094

Scheme 4. Synthetic Scheme for the Preparation of 4-Cyano-phenylpropenyl Compounds 24a and 24b Lacking the Adenosine Unit.

Scheme 4

Reagents and conditions are as follows: (a) methylamine in MeOH (33% w/w), NaBH(OAc)3, AcOH, DCE, rt, overnight (42%); (b) aldehyde 22, NaBH(OAc)3, AcOH, DCE, rt, overnight (48–77%); (c) TFA, CH2Cl2, H2O, rt, 2 h, (75–87%).