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. 2021 Sep 2;24(5):760. doi: 10.3892/mmr.2021.12400

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Copyright: © Ding et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effects of SIRT2 knockdown on RAS/ERK signaling. (A) Comparison of the mRNA expression levels of HRAS between the Sh-NC and Sh-SIRT2 groups in NCI-H929 cells. (B and C) Comparison of HRAS, ERK and p-ERK protein expression levels between Sh-NC and Sh-SIRT2 groups in NCI-H929 cells. (D) Comparison of the mRNA expression levels of HRAS between the Sh-NC and Sh-SIRT2 groups in RPMI-8226 cells. (E and F) Comparison of HRAS, ERK and p-ERK protein expression levels between the Sh-NC and Sh-SIRT2 groups in RPMI-8226 cells. *P<0.05, **P<0.01, ***P<0.001. SIRT2, sirtuin 2; Sh-SIRT2, shRNA-SIRT2; Sh-NC, shRNA-negative control; shRNA, short hairpin RNA; p-ERK, phosphorylated-ERK.