Skip to main content
. 2021 Aug 9;12(9):1389–1395. doi: 10.1021/acsmedchemlett.1c00048

Table 2. Physiochemical Properties and Brain-to-Plasma Ratios (AUCbrain/AUCplasma) of Anti-AβO Compounds.

cmpd MW cLogP tPSA Brain/plasma AUC Brain/plasma 24 h postdose
(R)-2 376.2 6.48 12.3 NT 8.2
3 341.8 5.89 12.0 NT 2.0
6 357.5 4.65 32.7 5.64 5.4
7 431.6 3.26 66.8 2.51 5.7