Table 4.
Laboratory Parameters on Admission
| Variable | N | Overall, N = 157a | Patient Outcome | p-valueb | |
|---|---|---|---|---|---|
| Survivor, N = 107a | Non-Survivors, N = 50a | ||||
| WBC (109/L) | 154 | 7.9 (5.7–10.8) | 7.2 (5.4–9.4) | 10.4 (6.3–14.9) | <0.001 |
| < 4 | 8 (5.2%) | 6 (5.8%) | 2 (4.0%) | ||
| 4–10 | 98 (64%) | 77 (74%) | 21 (42%) | ||
| > 10 | 48 (31%) | 21 (20%) | 27 (54%) | ||
| ANC (109/L) | 154 | 5.9 (3.8–9.2) | 5.4 (3.5–8.0) | 8.3 (5.0–13.9) | <0.001 |
| < 1.8 | 3 (1.9%) | 3 (2.9%) | 0 (0%) | ||
| 1.8–6.3 | 81 (53%) | 62 (60%) | 19 (38%) | ||
| > 6.3 | 70 (45%) | 39 (38%) | 31 (62%) | ||
| ALC (109/L) | 154 | 0.89 (0.65–1.45) | 0.88 (0.65–1.37) | 1.00 (0.67-1.63) | 0.47 |
| < 0.8 | 64 (42%) | 44 (42%) | 20 (40%) | ||
| 0.8–1.0 | 20 (13%) | 15 (14%) | 5 (10%) | ||
| > 1.0 | 70 (45%) | 45 (43%) | 25 (50%) | ||
| CRP (mg/L) | 151 | 134 (52–267) | 109 (47–220) | 207 (90–301) | 0.004 |
| < 50 | 37 (25%) | 29 (28%) | 8 (17%) | ||
| 50–100 | 23 (15%) | 18 (17%) | 5 (10%) | ||
| 100–200 | 37 (25%) | 26 (25%) | 11 (23%) | ||
| > 200 | 54 (36%) | 30 (29%) | 24 (50%) | ||
| LDH (IU/L) | 139 | 446 (304–576) | 392 (282–533) | 504 (412–728) | 0.002 |
| ≤ 225 | 16 (12%) | 14 (15%) | 2 (4.3%) | ||
| > 225 | 123 (88%) | 79 (85%) | 44 (96%) | ||
| D-dimer (mg/L) | 134 | 0.68 (0.39–1.93) | 0.58 (0.35–1.34) | 1.44 (0.58–5.74) | <0.001 |
| < 0.5 | 46 (34%) | 39 (41%) | 7 (18%) | ||
| 0.5–1.0 | 32 (24%) | 21 (22%) | 11 (28%) | ||
| > 1.0 | 56 (42%) | 34 (36%) | 22 (55%) | ||
| Ferritin (µg/L) | 118 | 928 (525–1843) | 960 (525–1905) | 829 (563–1573) | 0.79 |
| Unknown | 39 | 21 | 18 | ||
| < 250 | 19 (16%) | 14 (16%) | 5 (16%) | ||
| 250–500 | 10 (8.5%) | 7 (8.1%) | 3 (9.7%) | ||
| > 500 | 88 (75%) | 65 (76%) | 23 (74%) | ||
| INR | 72 | 1.15 (1.10–1.34) | 1.13 (1.07–1.27) | 1.25 (1.15–1.64) | 0.007 |
| 0–1 | 4 (5.6%) | 3 (6.5%) | 1 (3.8%) | ||
| 1.0–1.5 | 56 (78%) | 38 (83%) | 18 (69%) | ||
| > 1.5 | 12 (17%) | 5 (11%) | 7 (27%) | ||
| BUN (mmol/L) | 118 | 5.9 (3.9–9.9) | 5.0 (3.3–7.6) | 8.2 (4.8–12.4) | <0.001 |
| ≤ 9.5 | 87 (74%) | 60 (83%) | 27 (59%) | ||
| > 9.5 | 31 (26%) | 12 (17%) | 19 (41%) | ||
| Creatinine (μmol/L) | 127 | 85 (72–114) | 82 (71–101) | 95 (76–134) | 0.040 |
| ≤ 104 | 88 (69%) | 63 (79%) | 25 (53%) | ||
| > 104 | 39 (31%) | 17 (21%) | 22 (47%) | ||
| AST (IU/L) | 81 | 49 (29–83) | 38 (25–66) | 64 (42–99) | 0.007 |
| ≤ 40 | 34 (42%) | 27 (54%) | 7 (23%) | ||
| > 40 | 47 (58%) | 23 (46%) | 24 (77%) | ||
| ALT (IU/L) | 82 | 35 (22–65) | 40 (22–67) | 33 (22–54) | 0.57 |
| ≤ 41 | 46 (56%) | 25 (50%) | 21 (66%) | ||
| > 41 | 36 (44%) | 25 (50%) | 11 (34%) | ||
Notes: aMedian (IQR) or frequency (%) bWilcoxon rank sum test; Fisher’s exact test; Pearson’s Chi-squared test.
Abbreviations: ANC, absolute neutrophil count; ALC, absolute lymphocyte count; CRP, C-reactive protein; LDH, lactate dehydrogenase; INR, international normalized ratio; BUN, blood urea nitrogen; AST, aspartate aminotransferase; ALT, alanine aminotransferase; <, less than; >, more than.