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. Author manuscript; available in PMC: 2021 Sep 13.
Published in final edited form as: J Mol Biol. 2021 Apr 20;433(17):166995. doi: 10.1016/j.jmb.2021.166995

Figure 6.

Figure 6.

Polysite model of K2P structural pharmacology. Central cartoon shows the locations of structurally defined K2P small molecule binding sites including the Keystone inhibitor site (magenta) (PDB: 6V3I),51 K2P modulator pocket (cyan) (PDB:6CQ8),37 Fenestration site (green) (PDB:4XDK),40 Modulatory lipid site (grey) (PDB:6W8C),53 and Vestibule site (orange) (PDB: 6RV3).38 Cap, Extracellular ion pathway (EIP), and ‘C-type’ SF gate are indicated. Potassium ions are shown (purple). Grey lines denote the lipid bilayer. Black boxes show the details of the individual sites. Grey boxes show modulator chemical structures. X-gate is not shown in the central cartoon.