Table 2:
Estimated ORs and 95% CIs for the association of Hypertension, Hyperlipidemia, Diabetes and EOC Risk*
| Cases |
Controls |
|||
|---|---|---|---|---|
| Comorbidity |
n(%) |
n(%) |
OR (95% CI)a |
OR (95% CI)b |
| History of HTN | ||||
| No | 205 (34.6) | 330 (43.9) | 1.00 (Referent) | 1.0 (Referent) |
| Yes | 388 (65.4) | 422 (56.1) | 1.11 (0.86, 1.83) | 1.32 (1.01, 1.73) |
| Duration of HTN | ||||
| Never diagnosed | 205 (34.6) | 330 (43.9) | 1.00 (Referent) | 1.0 (Referent) |
| <10 years | 187 (31.5) | 184 (24.5) | 1.33 (0.99, 1.79) | 1.59 (1.17, 2.16) |
| ≥ 10 years | 201 (33.9) | 238 (31.6) | 0.92 (0.68, 1.24) | 1.10 (0.81, 1.50) |
| History of DM | ||||
| No | 463 (78.1) | 576 (76.6) | 1.00 (Referent) | 1.00 (Referent) |
| Yes | 130 (21.9) | 176 (23.4) | 0.63 (0.47, 0.84) | 0.67 (0.49, 0.91) |
| Duration of DM | ||||
| Never diagnosed | 463 (78.1) | 576 (76.6) | 1.00 (Referent) | 1.00 (Referent) |
| <10 years | 70 (11.8) | 102 (13.6) | 0.64 (0.45, 0.92) | 0.68 (0.48, 0.98) |
| ≥ 10 years | 60 (10.1) | 74 (9.8) | 0.61 (0.41, 0.92) | 0.66 (0.44, 1.00) |
| History of HLD | ||||
| No | 398 (67.1) | 473 (62.9) | 1.00 (Referent) | 1.00 (Referent) |
| Yes | 195 (32.9) | 279 (37.1) | 0.60 (0.46, 0.77) | 0.61 (0.47, 0.80) |
| Duration of HLD | ||||
| Never diagnosed | 398 (67.1) | 473 (62.9) | 1.00 (Referent) | 1.00 (Referent) |
| <10 years | 114 (19.2) | 183 (24.3) | 0.58 (0.43, 0.79) | 0.59 (0.44, 0.80) |
| ≥ 10 years | 81 (13.7) | 96 (12.7) | 0.63 (0.44, 0.90) | 0.64 (0.44, 0.93) |
| Combination | ||||
| None | 101 (26.2) | 246 (32.7) | 1.00 (Referent) | |
| HTN only | 118 (30.6) | 157 (20.9) | 1.16 (0.84, 1.61) | |
| HLD only | 15 (3.9) | 55 (7.3) | 0.35 (0.19, 0.65) | |
| DM only | 5 (1.3) | 17 (2.3) | 0.26 (0.09, 0.74) | |
| HTN & HLD | 62 (16.1) | 118 (15.7) | 0.67 (0.46, 0.99) | |
| HTN & DM | 28 (7.3) | 53 (7.0) | 0.63 (0.38, 1.05) | |
| HLD & DM | 3 (0.8) | 12 (1.6) | 0.40 (0.14, 1.14) | |
| HTN, HLD & DM | 53 (13.8) | 94 (12.5) | 0.58 (0.38, 0.89) |
EOC: epithelial ovarian cancer; OR: odds ratio; CI: confidence interval; HTN: hypertension; HLD: hyperlipidemia; DM: diabetes mellitus; OCP: oral contraceptive pill; BMI: body mass index
*
Among cases, presence of HTN, DM, or HLD must precede cancer diagnosis. Cases that developed these co-morbidities after their cancer diagnosis were not included as having HTN, DM, or HLD.
a
Models adjusted for age, site, parity, family history, OCP use, BMI and education
b
Models adjusted for age, site, parity, family history, OCP use, BMI, education and presence of the other co-morbidities