Table 3.

Studies investigating neurotoxicity in patients with CF

Reference	Mode of administration	Colistin dose	Days on colistin	Neurotoxicity cases in patients with CF	Type of neurotoxicity
[11]	IV and nebulized	150 mg, nebulized q8h 1.25 mg/kg	N/R, the reaction occurred with the first dose	4	Perioral paresthesia; tingling in hands, face, fingertips, knee and jaw
[12]	IV and nebulized	5 mg/kg	7–30	0/6	None
[13]	IV	N/R	9	2	Paresthesia, bad taste
[14]	IV	5–7 mg/kg/d	6–35	26/31	Oral and perioral paresthesia, headache and lower extremity weakness
[15]	Parenteral	N/R	N/R	0	None
[16]	IV	1.63–3.11 mg/kg	2	0/12	None
[17]	IV	2 MU t.d.s.	1–14	0/52	None
[18]	IV	5.3–12.9 mg/kg	12	37/53	Dizziness, numbness, tingling, incoordination, unsteadiness and muscle weakness
[19]	IV	N/R	N/R	6/19	Perioral paresthesia, ataxia

Abbreviations: IV, intravenous; MU, million units; N/R, not registered; t.d.s., three times a day.