Table III.

Kyoto Encyclopedia of Genes and Genomes pathway functional enrichment analysis.

Rank	ID	Term	List hits	List total	Population hits	Population total	P-value
1	5200	Pathways in cancer	131	1,399	327	5,981	3.51×10−12
2	4010	MAPK signaling pathway	115	1,399	268	5,981	3.68×10−13
3	4810	Regulation of actin cytoskeleton	95	1,399	214	5,981	4.37×10−12
4	4510	Focal adhesion	94	1,399	200	5,981	8.62×10−14
5	4144	Endocytosis	84	1,399	203	5,981	5.40×10−9
6	4310	Wnt signaling pathway	71	1,399	151	5,981	1.02×10−10
7	4360	Axon guidance	69	1,399	130	5,981	1.27×10−13
8	4020	Calcium signaling pathway	60	1,399	177	5,981	8.32×10−4
9	4141	Protein processing in endoplasmic reticulum	56	1,399	167	5,981	1.63×10−3
10	4120	Ubiquitin mediated proteolysis	53	1,399	139	5,981	5.85×10−5
11	4722	Neurotrophin signaling pathway	51	1,399	127	5,981	1.56×10−5
12	4530	Tight junction	48	1,399	133	5,981	5.75×10−4
13	4151	PI3K/AKT signaling pathway	46	1,399	138	5,981	4.63×10−3
14	4514	Cell adhesion molecules (CAMs)	42	1,399	136	5,981	2.61×10−2
15	4660	T cell receptor signaling pathway	42	1,399	108	5,981	2.03×10−4

‘List hits’ indicates the number of genes annotated by the considered KEGGpathwaycategory or annotation cluster within the analyzed list of target genes. ‘List total’ indicates the number of genes within the analyzed list of target genes having at least one KEGG pathwayannotation. ‘Population hits’ indicates the number of genes, available on the entire microarray, annotated by the considered KEGG pathway category or annotation cluster. ‘Population total’ indicates the number of genes available on the entire microarray and having at least one KEGG pathway annotation. P-value indicates the significance P-value of the gene enrichment of the considered KEGG pathwaycategory or annotation cluster, calculated with a unilateral Fisher's exact test. KEGG, Kyoto Encyclopedia of Genes and Genomes.