Table 1. S. aureus and E. coli DNA Gyrase, TopoIV, and Human Topoisomerase IIα Inhibitory Activity and Physico-Chemical Properties of the Optimized Series of NBTIs.
a
Means of two independent measurements ± SD.
b
DNA gyrase supercoiling inhibition assay.
c
TopoIV decatenation inhibition assay.
d
Means ± SD of the residual activity (%) at a 10 μM compound concentration from two independent experiments.
e
clogP, logD, and pKa were calculated with MarvinSketch ver. 20.17. logD and pKa values are calculated at pH 7.4; ND, not determined.
f
Ref (31).