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. Author manuscript; available in PMC: 2021 Sep 13.
Published in final edited form as: Nature. 2020 Jul 30;586(7830):578–582. doi: 10.1038/s41586-020-2608-y

Figure 2. Humoral and cellular immune responses to ChAdOx1 nCoV-19 vaccination in rhesus macaques.

Figure 2.

a. Study schedule for NHPs. V = vaccination; E = exam; C = exam and challenge; N = exam and necropsy. Violin plots of b. endpoint IgG titer in serum against trimeric spike protein, c. VN titer in serum and d. Summed IFN-γ ELISpot responses in PBMCs collected at 0 DPI toward peptides spanning the spike protein. Red circles = prime-only vaccine; blue squares = prime-boost vaccine; green triangle = controls; dotted line = limit of detection; SFU = spot-forming units; VN= virus-neutralizing; * = p-value=0.0313. Statistical significance determined via two-tailed Wilcoxon test.